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When Los Angeles Rams take on the Jacksonville Jaguars at Wembley Stadium on , the NFL’s International Series adds another chapter to its London saga. Both clubs entered the matchup at 4‑2, but the stakes feel richer than a simple win‑loss column – it’s about global brand, betting lines, and a rookie coach trying to prove his system on foreign turf.

Why This Game Matters Beyond the Scoreboard

The 2025 NFL International SeriesWembley Stadium isn’t just another regular‑season contest. Since 2007, the league has used the London stage to showcase marquee teams and test the appetite of a growing overseas fanbase. For the Jaguars, it’s a chance to leverage their surprising comfort with transatlantic travel – they’ve logged more games in England than any other franchise this decade. For the Rams, it’s a test of Sean McVay’s coaching pedigree in an environment that’s rarely his home field.

Betting Lines: The Numbers Talk

Action Network’s Brandon Anderson – who’s been tracking the odds for the past 30 days with a 110‑133‑5 record – says the Rams sit 0.9 units as -105 favorites. The spread reads Rams -3 (a typo in the raw feed listed -45, clearly an error) while the total is set at 45 points. In plain English, a bettor backing Los Angeles would need a 4‑point margin for a win; backing Jacksonville would win a razor‑thin 21‑17 prediction that Sports Gambler floated.

  • Rams Moneyline: -156
  • Jaguars Moneyline: +131
  • Spread: Rams -3, Jaguars +3
  • Over/Under: 45 points

Winners & Whiners reported a slightly tighter spread – Rams 1.5 points – and a game total of 44.5. The variation isn’t huge, but it tells us the market is still feeling out the impact of recent injuries and coaching narratives.

Key Players and Coaching Stories

On the Rams’ side, Sean McVay, head coach, brings a playbook that’s been tested in London before – he coached the 2018 Rams‑London game that drew a record crowd. His offensive scheme relies heavily on quick‑pass concepts that could exploit Jacksonville’s shaky O‑line.

Opposite him, Liam Coen, first‑year head coach of the Jaguars, leads what Action Network calls the league’s "youngest, most inexperienced staff." Coen’s biggest asset? The Jaguars have played more games in England than any other team this season, a point that some analysts say could act like a pseudo‑home‑field advantage.

Quarterback Trevor Lawrence has been under pressure, sacked ten times in the past two weeks. If the Rams’ defensive front can maintain that pressure, Jacksonville’s passing attack could sputter.

Recent Performances: Form Guides

Just a week before the London showdown, the Rams thumped the Baltimore Ravens 17‑3 at M&T Bank Stadium, amassing 241 total yards (167 passing, 74 rushing) and showing a defensive DVOA that sits in the top five league‑wide. Their offense, while efficient, still wrestles with the absence of wideout Puka Nacua, who’s listed as questionable with a lingering thigh injury.

The Jaguars, meanwhile, fell 20‑12 to the Seattle Seahawks at EverBank Stadium. They recorded 273 total yards (214 passing, 59 rushing) but couldn’t convert enough red‑zone opportunities. Their DVOA hovers near the league average, suggesting they’re competitive but not yet elite on either side of the ball.

Expert Takes: What the Odds Whisper

Action Network’s analysts argue the Rams’ top‑five DVOA rankings on both offense and defense give them a measurable edge. The Jaguars, by contrast, are "close to average at all three facets of the game," which translates to a betting line that leans just enough to keep the market interested.

Still, the narrative of experience in London can’t be ignored. The Jaguars have played four games in the UK since 2022, while the Rams have only two overseas appearances in the same span. Some bettors are betting on the travel‑savvy Jags to upset the odds, especially if the Rams’ offense looks tentative without Nacua.

Broader Implications: NFL’s Global Push

London’s capacity to host 90,000 fans for an NFL game – a number that rivals many NFL stadiums – underscores the league’s ambition to turn the UK into a second home market. Success for either team could translate into higher TV ratings on NFL Network and more merchandise sales for their respective brands abroad.

If the Rams win, Sean McVay adds another feather to his cap, reinforcing the idea that his coaching can thrive in any environment. A Jaguars victory, however, would be a boost for Liam Coen’s résumé, proving that a rookie coaching staff can manage the pressures of a global stage.

What Happens Next?

After the game, the Rams will travel back to the West Coast for a Week 8 showdown with the Denver Broncos, while the Jaguars head home to face the New England Patriots. Both teams will be carrying the weight of their London performance into the next stretch of the season, where playoff positioning starts to get real.

For bettors, the key will be monitoring injury updates – especially Nacua’s status – up until kickoff. The line could shift as sportsbooks react to the final health reports.

Historical Context: Past Encounters

The last meeting between these clubs was a 37‑7 Rams blowout at SoFi Stadium in 2021. That result gave Los Angeles a psychological edge, but it’s been four years and two different coaching regimes since. The Jaguars have turned that memory into motivation, eager to rewrite the narrative on foreign soil.

Frequently Asked Questions

How does the Rams’ injury situation affect their chances?

The Rams are missing starter wideout Puka Nacua due to a thigh strain. Without his speed, the passing game might lean more on short routes, which could make the offense easier to defend against the Jaguars’ aggressive front.

What advantage does Jacksonville have playing in London?

The Jaguars have logged more games in England than any other NFL team this decade, giving them familiarity with travel logistics, time‑zone adjustments, and the stadium’s turf. That experience could help them stay sharp while the Rams adjust to the overseas setting.

Will the betting line likely move before kickoff?

Yes. As the league releases the final injury report – especially regarding Nacua and the Jaguars’ offensive line – sportsbooks tend to adjust the spread. A late‑breaking update could tighten the Rams’ advantage or even swing the line in Jacksonville’s favor.

What does a win mean for Sean McVay’s legacy?

A victory in London would reinforce McVay’s reputation as a coach who can prepare his team for any environment. It adds an international trophy to his résumé, bolstering his case for future Hall‑of‑Fame discussions.

How will this game affect the NFL’s expansion plans?

Strong attendance and TV ratings from this matchup would encourage the league to keep or even increase its London slate. Conversely, a lackluster performance or low viewership could prompt officials to reassess the market’s long‑term viability.